Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels

@article{JurkovicovaTarabova2019IdentificationOA,
  title={Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels},
  author={Bohumila Jurkovicova-Tarabova and Leos Cmarko and Renata Rehak and Gerald W. Zamponi and Ľubica Lacinov{\'a} and Norbert Weiss},
  journal={Molecular Brain},
  year={2019},
  volume={12}
}
The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it is essential to develop a clear understanding of the structural determinants responsible for the unique gating features of T-type channels. Here, we have investigated the specific role of the carboxy terminal region by creating a series a deletion constructs expressed in tsA-201 cells and… 

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