Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization.

@article{Marobbio2006IdentificationOA,
  title={Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization.},
  author={Carlo Marya Thomas Marobbio and Maria Antonietta Di Noia and Ferdinando Palmieri},
  journal={The Biochemical journal},
  year={2006},
  volume={393 Pt 2},
  pages={
          441-6
        }
}
Pyrimidine (deoxy)nucleoside triphosphates are required in mitochondria for the synthesis of DNA and the various types of RNA present in these organelles. In Saccharomyces cerevisiae, these nucleotides are synthesized outside the mitochondrial matrix and must therefore be transported across the permeability barrier of the mitochondrial inner membrane. However, no protein has ever been found to be associated with this transport activity. In the present study, Rim2p has been identified as a yeast… 

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