Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

@article{Shaulian1992IdentificationOA,
  title={Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.},
  author={Eitan Shaulian and Ayelet Zauberman and Doron Ginsberg and Moshe Oren},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 12},
  pages={
          5581-92
        }
}
Mutations in the p53 gene are most frequent in cancer. Many p53 mutants possess transforming activity in vitro. In cells transformed by such mutants, the mutant protein is oligomerized with endogenous cell p53. To determine the relevance of oligomerization for transformation, miniproteins containing C-terminal portions of p53 were generated. These miniproteins, although carrying no point mutation, transformed at least as efficiently as full-length mutant p53. Transforming activity was coupled… CONTINUE READING

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