Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.

@article{Heng2012IdentificationOA,
  title={Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.},
  author={X. Heng and S. Kharytonchyk and Eric L. Garcia and Kun Lu and S. Divakaruni and Courtney LaCotti and Kedy Edme and A. Telesnitsky and M. Summers},
  journal={Journal of molecular biology},
  year={2012},
  volume={417 3},
  pages={
          224-39
        }
}
Assembly of human immunodeficiency virus type 1 (HIV-1) particles is initiated in the cytoplasm by the formation of a ribonucleoprotein complex comprising the dimeric RNA genome and a small number of viral Gag polyproteins. Genomes are recognized by the nucleocapsid (NC) domains of Gag, which interact with packaging elements believed to be located primarily within the 5'-leader (5'-L) of the viral RNA. Recent studies revealed that the native 5'-L exists as an equilibrium of two conformers, one… Expand
Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
Structure of the HIV-1 RNA packaging signal
In Vivo SELEX of Single-Stranded Domains in the HIV-1 Leader RNA
Identification of a Novel Cis-Acting Regulator of HIV-1 Genome Packaging
New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 123 REFERENCES
RNA Structure and Packaging Signals in the 5′ Leader Region of the Human Immunodeficiency Virus Type 1 Genome
NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging
Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1.
Possible Role of Dimerization in Human Immunodeficiency Virus Type 1 Genome RNA Packaging
...
1
2
3
4
5
...