Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.

@article{Heng2012IdentificationOA,
  title={Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.},
  author={Xiao Heng and Siarhei Kharytonchyk and Eric L. Garcia and Kun Lu and Sai Sachin Divakaruni and Courtney LaCotti and Kedy Edme and Alice Telesnitsky and Michael F Summers},
  journal={Journal of molecular biology},
  year={2012},
  volume={417 3},
  pages={
          224-39
        }
}
Assembly of human immunodeficiency virus type 1 (HIV-1) particles is initiated in the cytoplasm by the formation of a ribonucleoprotein complex comprising the dimeric RNA genome and a small number of viral Gag polyproteins. Genomes are recognized by the nucleocapsid (NC) domains of Gag, which interact with packaging elements believed to be located primarily within the 5'-leader (5'-L) of the viral RNA. Recent studies revealed that the native 5'-L exists as an equilibrium of two conformers, one… CONTINUE READING

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