Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin.

@article{Geething2007IdentificationOA,
  title={Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin.},
  author={Nathan C. Geething and James A Spudich},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 29},
  pages={21518-28}
}
Myosin V is a molecular motor that transports a variety of cellular cargo, including organelles, vesicles, and messenger RNA. The proper peripheral distribution of melanosomes, a dense pigment-containing organelle, is dependent on actin and the activity of myosin Va. The recruitment of myosin Va to the melanosome and proper transport of the melanosome requires melanophilin, which directly binds to myosin Va and is tethered to the melanosome membrane via Rab27a. Here we use highly purified… CONTINUE READING

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