Identification of a membrane skeleton in platelets

  title={Identification of a membrane skeleton in platelets},
  author={Jennifer E. Fox and J K Boyles and Michael C. Berndt and Peter Steffen and Lamont K. Anderson},
  journal={The Journal of Cell Biology},
  pages={1525 - 1538}
Platelets have previously been shown to contain actin filaments that are linked, through actin-binding protein, to the glycoprotein (GP) Ib-IX complex, GP Ia, GP IIa, and an unidentified GP of Mr 250,000 on the plasma membrane. The objective of the present study was to use a morphological approach to examine the distribution of these membrane-bound filaments within platelets. Preliminary experiments showed that the Triton X-100 lysis buffers used previously to solubilize platelets completely… CONTINUE READING