Identification of a membrane estrogen receptor in zebrafish with homology to mammalian GPER and its high expression in early germ cells of the testis.

@article{Liu2009IdentificationOA,
  title={Identification of a membrane estrogen receptor in zebrafish with homology to mammalian GPER and its high expression in early germ cells of the testis.},
  author={Xiaochun Liu and Pei Hong Zhu and Kathy Wai-Yan Sham and Jacky M L Yuen and Chuanming Xie and Yong Zhang and Yun Liu and Shuisheng Li and Xigui Huang and Christopher H. K. Cheng and Hao Lin},
  journal={Biology of reproduction},
  year={2009},
  volume={80 6},
  pages={1253-61}
}
To study the rapid action of estrogen on the male reproductive system in teleost, a full-length cDNA homologous to the seven-transmembrane receptor GPER of humans and rodents was cloned from the testis of zebrafish. Biological characterization of this cloned zebrafish gper was performed based on its functional expression in cultured eukaryotic cells. Saturation analysis and Scatchard plotting of [(3)H]-estradiol binding to plasma membranes of gper-transfected COS-7 cells and cAMP response… CONTINUE READING

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