Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.

@article{Fuse1996IdentificationOA,
  title={Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.},
  author={Nobuo Fuse and Ken ichi Yasumoto and Hiroshi Suzuki and Kazuhiro Takahashi and Shigeki Shibahara},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={219 3},
  pages={702-7}
}
Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for an essential enzyme in melanin biosynthesis. In this study, we have cloned and characterized the human genomic DNA segment containing a melanocyte-type exon and its 5'-flanking region of the MITF gene. A major transcriptional initiation site was assigned by primer extension and S1 nuclease mapping… CONTINUE READING

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