Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions

@inproceedings{McNeil2015IdentificationOA,
  title={Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions},
  author={Benjamin D. McNeil and Priyanka Pundir and Sonya N Meeker and Liang Han and Bradley J Undem and Marianna Kulka and Xinzhong Dong},
  booktitle={Nature},
  year={2015}
}
Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a unique property of mast cells is their antibody-independent responsiveness to a range of cationic substances, collectively called basic secretagogues, including inflammatory peptides and drugs associated with allergic-type reactions. The… CONTINUE READING
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