Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

@article{Wei1992IdentificationOA,
  title={Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.},
  author={Wenxiang Wei and Raymond D. Mosteller and P Sanyal and Enrique Moreno Gonzales and Denise McKinney and Chiranjib Dasgupta and Peng Li and Bin Liu and Daniel Broek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 15},
  pages={7100-4}
}
The yeast Saccharomyces cerevisiae CDC25 gene encodes a nucleotide-exchange-factor (NEF) that can convert the inactive GDP-bound state of RAS proteins to an active RAS-GTP complex. CDC25 can activate the yeast RAS proteins as well as the human H-ras protein. CDC25 is a member of a family of yeast genes that likely encode NEFs capable of regulating the RAS-related proteins found in yeast. By aligning the amino acid sequence of CDC25-related gene products we found a number of conserved motifs… CONTINUE READING
Highly Cited
This paper has 147 citations. REVIEW CITATIONS
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

147 Citations

02040'93'98'04'10'16
Citations per Year
Semantic Scholar estimates that this publication has 147 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…