Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.

  title={Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.},
  author={Alex Desautels and Gustavo Turecki and Jacques Y. Montplaisir and Adolfo Sequeira and Andrei Verner and G. A. Rouleau},
  journal={American journal of human genetics},
  volume={69 6},
Restless legs syndrome (RLS) is a neurological disorder characterized by leg paresthesia associated with an irresistible urge to move that often interferes with nocturnal sleep, leading to chronic sleep deprivation. To map genes that may play a role in the vulnerability to RLS, a genomewide scan was conducted in a large French-Canadian family. Significant linkage was established on chromosome 12q, for a series of adjacent microsatellite markers with a maximum two-point LOD score of 3.42… 

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