Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells.

@article{Kerjaschki1986IdentificationOA,
  title={Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells.},
  author={Dontscho Kerjaschki and Helga Poczewski and Gerhard Dekan and Reinhard Horvat and Egon Balzar and Nina Kraft and Robert C. Atkins},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={78 5},
  pages={1142-9}
}
Glomerular visceral epithelial cells are endowed with a sialic acid-rich surface coat (the "glomerular epithelial polyanion"), which in rat tissue contains the sialoprotein podocalyxin. We have identified a major membrane sialoprotein in human glomeruli that is similar to rat podocalyxin in its sialic acid-dependent binding of wheat germ agglutinin and in its localization on the surface of glomerular epithelial and endothelial cells, as shown by immunoelectron microscopy, using the monoclonal… CONTINUE READING

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