Identification of a major recombination hotspot in patients with short stature and SHOX deficiency.

@article{Schneider2005IdentificationOA,
  title={Identification of a major recombination hotspot in patients with short stature and SHOX deficiency.},
  author={Katja Ute Schneider and Nitin Sabherwal and Karin Jantz and Ralph Roeth and Nadja Muncke and Werner Friedrich Blum and Gordon B. Cutler and Gudrun A Rappold},
  journal={American journal of human genetics},
  year={2005},
  volume={77 1},
  pages={89-96}
}
Human growth is influenced not only by environmental and internal factors but also by a large number of different genes. One of these genes, SHOX, is believed to play a major role in growth, since defects in this homeobox-containing gene on the sex chromosomes lead to syndromal short stature (Leri-Weill dyschondrosteosis, Langer mesomelic dysplasia, and Turner syndrome) as well as to idiopathic short stature. We have analyzed 118 unrelated patients with Leri-Weill dyschondrosteosis and >1,500… CONTINUE READING

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