Identification of a major polypeptide of the nuclear pore complex

  title={Identification of a major polypeptide of the nuclear pore complex},
  author={Larry Gerace and Yvonne L. Ottaviano and C Kondor-Koch},
  journal={The Journal of Cell Biology},
  pages={826 - 837}
The nuclear pore complex is a prominent structural component of the nuclear envelope that appears to regulate nucleoplasmic molecular movement. Up to now, none of its polypeptides have been defined. To identify possible pore complex proteins, we fractionated rat liver nuclear envelopes and microsomal membranes with strong protein perturbants into peripheral and intrinsic membrane proteins, and compared these fractions on SDS gels. From this analysis, we identified a prominent 190-kilodalton… CONTINUE READING


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