Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype.

@article{Silver1995IdentificationOA,
  title={Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype.},
  author={Phyllis B. Silver and Luiz Vicente Rizzo and Chi Chao Chan and Larry A. Donoso and Barbara N Wiggert and Rachel R Caspi},
  journal={Investigative ophthalmology & visual science},
  year={1995},
  volume={36 5},
  pages={946-54}
}
PURPOSE Mice of the H-2b, H-2k, and H-2r haplotypes develop experimental autoimmune uveoretinitis (EAU) after immunization with interphotoreceptor retinoid-binding protein (IRBP) of bovine or monkey origin. The purpose of this study was to identify putative pathogenic epitope(s) of IRBP and to establish their immunodominance within the IRBP molecule. METHODS Overlapping 20-amino acid peptides, spanning the entire human IRBP molecule, were synthesized and used to immunize C57BL/10 (H-2b), B10… CONTINUE READING

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