Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype.

Abstract

PURPOSE Mice of the H-2b, H-2k, and H-2r haplotypes develop experimental autoimmune uveoretinitis (EAU) after immunization with interphotoreceptor retinoid-binding protein (IRBP) of bovine or monkey origin. The purpose of this study was to identify putative pathogenic epitope(s) of IRBP and to establish their immunodominance within the IRBP molecule… (More)

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@article{Silver1995IdentificationOA, title={Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype.}, author={P B Silver and Leonardo Rizzo and C. C. Chan and Larry A. Donoso and Barbara N Wiggert and Rachel R Caspi}, journal={Investigative ophthalmology & visual science}, year={1995}, volume={36 5}, pages={946-54} }