• DOI:10.1038/381661A0
Corpus ID: 37973935

Identification of a major co-receptor for primary isolates of HIV-1

@article{Deng1996IdentificationOA,
  title={Identification of a major co-receptor for primary isolates of HIV-1},
  author={H. Deng and R. Liu and W. Ellmeier and S. Choe and D. Unutmaz and Michael Burkhart and P. D. Marzio and S. Marmon and R. Sutton and C. Hill and C. B. Davis and S. Peiper and T. Schall and D. Littman and N. Landau},
  journal={Nature},
  year={1996},
  volume={381},
  pages={661-666}
}

• H. Deng, R. Liu, +12 authors N. Landau
• Published 1996
• Biology, Medicine
• Nature

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor… Expand

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