Identification of a major co-receptor for primary isolates of HIV-1

@article{Deng1996IdentificationOA,
  title={Identification of a major co-receptor for primary isolates of HIV-1},
  author={Hongkui Deng and Rong Liu and Wilfried Ellmeier and Sunny S Choe and Derya Unutmaz and Michael Burkhart and Paola Di Marzio and Shoshana Marmon and Richard E Sutton and C. Mark Hill and Craig B. Davis and Stephen C. Peiper and Thomas J. Schall and Dan R. Littman and Nathaniel R. Landau},
  journal={Nature},
  year={1996},
  volume={381},
  pages={661-666}
}
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor… Expand
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