Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

@article{Li2016IdentificationOA,
  title={Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.},
  author={Cecilia W. P. Li and Sophie Lev and Adolfo Saiardi and Desmarini Desmarini and Tania C Sorrell and Julianne Teresa Djordjevic},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={
          23927
        }
}
Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1Δ), and in combination with KCS1 (ipk1Δkcs1Δ), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence… CONTINUE READING
BETA
1
Twitter Mention

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES