Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes.

@article{Kelleher1992IdentificationOA,
  title={Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes.},
  author={Michael Kelleher and Antony Bacic and Emanuela Handman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 1},
  pages={6-10}
}
Leishmania are obligatory intracellular parasites in mammalian macrophages that gain entry by receptor-mediated phagocytosis. Their major cell surface glycoconjugate, lipophosphoglycan (LPG), has been implicated in this process. A monoclonal antibody specific for Leishmania major LPG (WIC 79.3), which has been shown to block promastigote attachment to macrophages, was used to identify a macrophage-binding determinant of LPG. WIC 79.3 bound exclusively to the phosphorylated repeats of LPG and… CONTINUE READING