Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor.

@article{Reddy2004IdentificationOA,
  title={Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor.},
  author={Sreelatha T. Reddy and Wengang Chai and Robert A. Childs and J Y S Danny Pag{\'e} and Ten E N Feizi and Nancy M. Dahms},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 37},
  pages={
          38658-67
        }
}
The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cation-dependent MPR (CD-MPR) are type I integral membrane glycoproteins that play a critical role in the intracellular delivery of newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases to the lysosome. The extracytoplasmic region of the CI-MPR contains 15 contiguous domains, and the two high affinity ( approximately 1 nm) Man-6-P-binding sites have been mapped to domains 1-3 and 9, with… CONTINUE READING

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