Identification of a locus on chromosome 1q44 for familial cold urticaria.

  title={Identification of a locus on chromosome 1q44 for familial cold urticaria.},
  author={Hal M. Hoffman and Fred A. Wright and David H. Broide and Alan A. Wanderer and Richard D Kolodner},
  journal={American journal of human genetics},
  volume={66 5},
Familial cold urticaria (FCU) is a rare autosomal dominant inflammatory disorder characterized by intermittent episodes of rash with fever, arthralgias, conjunctivitis, and leukocytosis. These symptoms develop after generalized exposure to cold. Some individuals with FCU also develop late-onset reactive renal amyloidosis, which is consistent with Muckle-Wells syndrome. By analyzing individuals with FCU from five families, we identified linkage to chromosome 1q44. Two-point linkage analysis… CONTINUE READING


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