Identification of a lithium interaction site in the gamma-aminobutyric acid (GABA) transporter GAT-1.

@article{Zhou2006IdentificationOA,
  title={Identification of a lithium interaction site in the gamma-aminobutyric acid (GABA) transporter GAT-1.},
  author={Yonggang Zhou and Elia Zomot and Baruch I. Kanner},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 31},
  pages={22092-9}
}
The sodium- and chloride-dependent electrogenic gamma-aminobutyric acid (GABA) transporter GAT-1, which transports two sodium ions together with GABA, is essential for synaptic transmission by this neurotransmitter. Although lithium by itself does not support GABA transport, it has been proposed that lithium can replace sodium at one of the binding sites but not at the other. To identify putative lithium selectivity determinants, we have mutated the five GAT-1 residues corresponding to those… CONTINUE READING

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