Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64.

@article{Juan1995IdentificationOA,
  title={Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64.},
  author={Todd S. -C. Juan and Eric Hailman and Michael J Kelley and Leigh Busse and Elyse Davy and Cyril J. Empig and Linda Owers Narhi and Samuel D. Wright and Henri S. Lichenstein},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 10},
  pages={5219-24}
}
CD14 is a 55-kDa glycoprotein which binds lipopolysaccharide (LPS) and enables LPS-dependent responses in a variety of cells. Recent limited proteolysis studies have implicated a region in CD14 between amino acids 57 and 64 as being involved in LPS interaction. To specifically assess the importance of this region with respect to LPS binding, we constructed a mutant sCD14 (sCD14 delta 57-64) lacking amino acids 57-64. sCD14 delta 57-64 was isolated from the serum-free conditioned medium of this… CONTINUE READING

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