Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.

@article{Notari2006IdentificationOA,
  title={Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.},
  author={Luigi Notari and Victoriano Baladr{\'o}n and Jos{\'e}-Daniel Aroca-Aguilar and Natalia Balko and Raul Jimenez Heredia and Christina Meyer and Patricia M Notario and Senthil S. Saravanamuthu and Mar{\'i}a-Luisa Nueda and F. S{\'a}nchez-S{\'a}nchez and Julio Escribano and Jorge Laborda and S Patricia Becerra},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 49},
  pages={38022-37}
}
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of retina, retinoblastoma, and CNS cells. This study was designed to reveal a receptor involved in the biological activities of PEDF. Using a yeast two… CONTINUE READING