Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells

@article{Plachta2007IdentificationOA,
  title={Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells},
  author={Nicolas Plachta and Christine Annaheim and Stephanie Bissi{\`e}re and Shuo Lin and Markus Rueegg and Sjouke Hoving and Dieter M{\"u}ller and Françoise Poirier and Miriam Bibel and Yves-Alain Barde},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={712-719}
}
Unlike the mechanisms involved in the death of neuronal cell bodies, those causing the elimination of processes are not well understood owing to the lack of suitable experimental systems. As the neurotrophin receptor p75NTR is known to restrict the growth of neuronal processes, we engineered mouse embryonic stem (ES) cells to express an Ngfr (p75NTR) cDNA under the control of the Mapt locus (the gene encoding tau), which begins to be active when ES cell–derived progenitors start elongating… CONTINUE READING