Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin.

  title={Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin.},
  author={Julie M Clements and Peter Newham and Malcolm Shepherd and R{\'e}nald Gilbert and Tim Dudgeon and Lindsey A. Needham and Richard M. Edwards and Loren Berry and Andrew Brass and Martin J Humphries},
  journal={Journal of cell science},
  volume={107 ( Pt 8)},
The integrin adhesion receptor alpha 4 beta 1 binds two ligands, the extracellular matrix glycoprotein fibronectin and the immunoglobulin superfamily member VCAM-1. Ligand-binding sites are contained with the HepII/IIICS domain of fibronectin, and within the homologous immunoglobulin domains 1 and 4 of VCAM-1. Previous studies have shown that the binding of each ligand to alpha 4 beta 1 is mutually exclusive, suggesting that they may employ similar mechanisms to bind receptor. Fibronectin… CONTINUE READING


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