Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent.

@article{Miller2004IdentificationOA,
  title={Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent.},
  author={Randall R Miller and George A. Doss and Ralph A Stearns},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 2},
  pages={178-85}
}
Glucuronides of piperazine hydroxylamines are rarely reported in the literature, and even more rarely are their structures unambiguously identified. One major metabolite was detected by liquid chromatography/mass spectrometry-radioactivity in urine from monkeys treated with the aryl piperazine oral hypoglycemic agent 9-[(1S,2R)-2-fluoro-1-methylpropyl]-2-methoxy-6-(1-piperazinyl) purine hydrochloride (1). The mass spectrum of this metabolite indicated that it was both monooxygenated and… CONTINUE READING

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