Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.

@article{Mori1991IdentificationOA,
  title={Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.},
  author={Shigehisa Mori and Lena Claesson-Welsh and C H Heldin},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 31},
  pages={21158-64}
}
The functional properties of carboxyl terminally truncated mutants of the platelet-derived growth factor beta-receptor were compared with those of the wild-type receptor and a receptor mutant made kinase negative by a point mutation. A mutant in which 98 amino acids were deleted retained kinase activity and mediated a mitogenic signal, whereas deletion of 141 or 155 amino acids led to loss of kinase activity and ability to mediate a mitogenic signal. The mutant with 155 amino acids deleted, i.e… CONTINUE READING
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The functional properties of carboxyl terminally truncated mutants of the platelet - derived growth factor beta - receptor were compared with those of the wild - type receptor and a receptor mutant made kinase negative by a point mutation .
The functional properties of carboxyl terminally truncated mutants of the platelet - derived growth factor beta - receptor were compared with those of the wild - type receptor and a receptor mutant made kinase negative by a point mutation .
A mutant in which 98 amino acids were deleted retained kinase activity and mediated a mitogenic signal , whereas deletion of 141 or 155 amino acids led to loss of kinase activity and ability to mediate a mitogenic signal .
A mutant in which 98 amino acids were deleted retained kinase activity and mediated a mitogenic signal , whereas deletion of 141 or 155 amino acids led to loss of kinase activity and ability to mediate a mitogenic signal .
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