Identification of a human neutrophil angiotension II-generating protease as cathepsin G.

  title={Identification of a human neutrophil angiotension II-generating protease as cathepsin G.},
  author={Marcia G. Tonnesen and Mark S. Klempner and K Frank Austen and Bruce U. Wintroub},
  journal={The Journal of clinical investigation},
  volume={69 1},
A human neutrophil protease, initially termed neutral peptide-generating protease, has been shown to cleave angiotensin II directly from angiotensinogen and has been identified as leukocyte cathepsin G. When purified neutrophils were disrupted by nitrogen cavitation and fractionated by differential centrifugation, 44 and 24% of the angiotensin II-generating activity was in the lysosomal and undisrupted cell fractions, respectively. Cytochalasin B-treated human neutrophils stimulated with N… CONTINUE READING


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