Identification of a human neonatal immune-metabolic network associated with bacterial infection

@inproceedings{Smith2014IdentificationOA,
  title={Identification of a human neonatal immune-metabolic network associated with bacterial infection},
  author={Claire L. Smith and Paul Dickinson and Thorsten Forster and Marie Craigon and Alan Ross and M. Reaz H. Khondoker and Rebecca France and Alasdair C. Ivens and David J. Lynn and Judith Orme and Allan Jackson and Paul Lacaze and Katie L Flanagan and Benjamin J. Stenson and Peter Ghazal},
  booktitle={Nature communications},
  year={2014}
}
Understanding how human neonates respond to infection remains incomplete. Here, a system-level investigation of neonatal systemic responses to infection shows a surprisingly strong but unbalanced homeostatic immune response; developing an elevated set-point of myeloid regulatory signalling and sugar-lipid metabolism with concomitant inhibition of lymphoid responses. Innate immune-negative feedback opposes innate immune activation while suppression of T-cell co-stimulation is coincident with… CONTINUE READING

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