Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs.

@article{Mller2011IdentificationOA,
  title={Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs.},
  author={Joachim M{\"u}ller and Andrew Hemphill},
  journal={Experimental parasitology},
  year={2011},
  volume={128 2},
  pages={
          145-50
        }
}
The thiazolide nitazoxanide (NTZ) and some derivatives exhibit considerable in vitro activities against a broad range of parasites, including the apicomplexans Neospora caninum and Toxoplasma gondii tachyzoites. In order to identify potential molecular targets for this compound in both parasites, RM4847 was coupled to epoxy-agarose and affinity chromatography was performed. A protein of approximately 35 kDa was eluted upon RM4847-affinity-chromatography from extracts of N. caninum-infected… Expand
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