Identification of a high-virulence clone of type III Streptococcus agalactiae (group B Streptococcus) causing invasive neonatal disease.

  title={Identification of a high-virulence clone of type III Streptococcus agalactiae (group B Streptococcus) causing invasive neonatal disease.},
  author={James M. Musser and Stephen J. Mattingly and Roland Quentin and Alain Goudeau and Robert K. Selander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 12},
Chromosomal genotypes of 128 isolates of six serotypes (Ia, Ib, Ic, II, Ic/II, and III) of Streptococcus agalactiae (group B Streptococcus) recovered predominantly from human infants in the United States were characterized by an analysis of electrophoretically demonstrable allelic profiles at 11 metabolic enzyme loci. Nineteen distinctive electrophoretic types (ETs), representing multilocus clonal genotypes, were identified. Mean genetic diversity per locus among ETs of isolates of the same… Expand
Characterization of Streptococcus agalactiae strains by multilocus enzyme genotype and serotype: identification of multiple virulent clone families that cause invasive neonatal disease
The characteristics of this French population argue for the existence of particular groups of strains responsible for neonatal meningitis and demonstrate that serotyping can supply information about the genetic distribution of strains. Expand
Identification of a highly encapsulated, genetically related group of invasive type III group B streptococci.
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Genetic diversity of rRNA operons of unrelated Streptococcus agalactiae strains isolated from cerebrospinal fluid of neonates suffering from meningitis
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Population structure of Streptococcus agalactiae reveals an association between specific evolutionary lineages and putative virulence factors but not disease
Combined analyses of data and those previously obtained by multilocus enzyme electrophoresis and serotyping revealed a population separating into six major lineages that correlate with individual serotypes, indicating that the S. agalactiae population examined is predominantly clonal. Expand
Long-Range Mapping of the Streptococcus agalactiae Phylogenetic Lineage Restriction Digest Pattern Type III-3 Reveals Clustering of Virulence Genes
It is suggested that the genetic variation that distinguishes the RDP type III-3 strains from other serotype III strains occurs largely within localized areas of the genome containing known or putative virulence genes. Expand
Population Structure of Invasive and Colonizing Strains of Streptococcus agalactiae from Neonates of Six U.S. Academic Centers from 1995 to 1999
The population structure of group B streptococci isolated from infected and colonized neonates during a prospective active-surveillance study of early-onset disease in six centers in the United States from July 1995 to June 1999 is described and its relationship to bovine strains is examined. Expand
Multilocus Sequence Typing of Swedish Invasive Group B Streptococcus Isolates Indicates a Neonatally Associated Genetic Lineage and Capsule Switching
Five major genetic lineages were identified among isolates of serotype III, indicating a highly clonal population structure among invasive GBS isolates, and the distribution of the mobile elements GBSi1 and IS1548 reveals that they can act as genetic markers for lineages CC17 and CC19, respectively. Expand
Equivalence of high-virulence clonotypes of serotype III group B Streptococcus agalactiae (GBS).
This study sought to unify phenotypic and genotypic classifications of type III GBS strains associated with increased virulence in newborns by identifying clonotypes of serotype III group B Streptococcus agalactiae associated with invasive infection in neonates. Expand
High-Virulence Clone of Group B Streptococci Unable to Grow at High Temperatures Is Present in Serotypes Other Than Type III
It is demonstrated that HVC is more prevalent in Mexico than previously reported and that this clone is not restricted to serotype III isolates. Expand
Emergence and Global Dissemination of Host-Specific Streptococcus agalactiae Clones
The composite structure of the S. agalactiae genome invalidates phylogenetic inferences exclusively based on multilocus sequence typing (MLST) data and thereby the previously reported conclusion that the human- associated CC17 emerged from the bovine-associated CC67 is invalid. Expand


Infectious Diseases of the Fetus and Newborn Infant
Infectious diseases of the fetus and newborn infant, Infectious diseases against pregnant women and newborn infants, and how to identify these diseases and treat them. Expand