Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor.

@article{Dougher1997IdentificationOA,
  title={Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor.},
  author={A M Dougher and Heather Wasserstrom and L W Torley and L Shridaran and P Westdock and Ronald E. Hileman and Jonathan R. Fromm and Robert J. Anderberg and S C Lyman and Robert J. Linhardt and Jerry Kaplan and Bruce I. Terman},
  journal={Growth factors},
  year={1997},
  volume={14 4},
  pages={257-68}
}
Vascular endothelial growth factor (VEGF), a potent and specific activator of endothelial cells, is expressed as multiple homodimeric forms resulting from alternative RNA splicing. VEGF121 does not bind heparin while the other three isoforms do, and it has been documented that the binding of VEGF165 to its receptor is dependent upon cell surface heparin sulfate proteoglycans. Little is known about the biochemical mechanism that allows for heparin regulation of growth factor binding. For example… CONTINUE READING

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