Identification of a growth factor mimicking the synergistic effect of fetal bovine serum on BMP-9 cell response.

@article{Lauzon2014IdentificationOA,
  title={Identification of a growth factor mimicking the synergistic effect of fetal bovine serum on BMP-9 cell response.},
  author={Marc-Antoine Lauzon and Alex Daviau and Olivier Drevelle and Bruno Marcos and Nathalie Faucheux},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 17-18},
  pages={
          2524-35
        }
}
The bone morphogenetic proteins (BMPs) are potent osteogenic molecules that are used for bone repair in delivery systems and in regenerative medicine. We studied the responses of murine MC3T3-E1 preosteoblasts to doses of recombinant human (rh)BMP-9 with and without fetal bovine serum (FBS). rhBMP-2 was used as a control since it is currently approved by the Food and Drug Administration for bone application. We analyzed the major cell signaling pathways and the expression of osteogenic markers… CONTINUE READING