Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.

@article{Sjstrm1998IdentificationOA,
  title={Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.},
  author={Hans Sj{\"o}str{\"o}m and Knut E. A. Lundin and Oyvind Molberg and Roman K{\"o}rner and Stephen McAdam and Dorit Anthonsen and Hanne Quarsten and Ove B Nor{\'e}n and Peter Roepstorff and Erik Thorsby and Ludvig M. Sollid},
  journal={Scandinavian journal of immunology},
  year={1998},
  volume={48 2},
  pages={111-5}
}
Coeliac disease probably results from a T-cell response to wheat gliadin and is associated to HLA-DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut-lesion-derived DQ2-restricted T cells from coeliac disease patients were used to identify an epitope within a purified gamma-type gliadin. The structure of the epitope was characterized by mass spectrometry and verified by synthesis. The epitope (QPQQSFPEQQ… CONTINUE READING

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