Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway.

@article{Lu2002IdentificationOA,
  title={Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway.},
  author={Li-Sheng Lu and James Tung and Nicole Baumgarth and O C Herman and Michael Gleimer and Leonard A. Herzenberg and Leonore Herzenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 5},
  pages={
          3007-12
        }
}
  • Li-Sheng Lu, James Tung, +4 authors Leonore Herzenberg
  • Published in
    Proceedings of the National…
    2002
  • Medicine, Biology
  • Studies presented here show that the expression of CD4, MHC class II (Ia,) and B220 cleanly resolves a major and a minor subset within the earliest pro-B cell population (germ-line pro-B) in adult bone marrow (BM). The major subset expresses intermediate B220 and low CD4 levels. The minor subset, which constitutes roughly 20% of the adult germ-line pro-B, expresses very low B220 levels and does not express CD4. Ia is clearly detectable at low levels on the major germ-line pro-B subset, both in… CONTINUE READING

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