Identification of a genetic locus essential for capsule sialylation in type III group B streptococci.

@article{Wessels1992IdentificationOA,
  title={Identification of a genetic locus essential for capsule sialylation in type III group B streptococci.},
  author={Michael R. Wessels and R F Haft and Laura M. Heggen and Craig E. Rubens},
  journal={Infection and immunity},
  year={1992},
  volume={60 2},
  pages={
          392-400
        }
}
The type III capsular polysaccharide of group B streptococci (GBS) consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid, or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule. We showed previously that a mutant strain of GBS that expressed a sialic acid-deficient, or asialo, form of the… CONTINUE READING

Citations

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