Identification of a gene required for membrane protein retention in the early secretory pathway.

@article{Nishikawa1993IdentificationOA,
  title={Identification of a gene required for membrane protein retention in the early secretory pathway.},
  author={Shuh-ichi Nishikawa and Akihiko Nakano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 17},
  pages={8179-83}
}
The yeast SEC12 gene product (Sec12p) is an integral membrane protein required for the protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus. Although this protein is almost exclusively localized in the ER, a significant fraction of Sec12p is modified by an enzyme that resides in the early compartment of the Golgi apparatus, suggesting that Sec12p is cycling between the ER and the early Golgi. We have taken a genetic approach to investigate the retention mechanism of… CONTINUE READING

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