Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data.

@article{Farber2010IdentificationOA,
  title={Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data.},
  author={Charles R. Farber},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010},
  volume={25 11},
  pages={2359-67}
}
Bone mineral density (BMD) is influenced by a complex network of gene interactions; therefore, elucidating the relationships between genes and how those genes, in turn, influence BMD is critical for developing a comprehensive understanding of osteoporosis. To investigate the role of transcriptional networks in the regulation of BMD, we performed a weighted gene coexpression network analysis (WGCNA) using microarray expression data on monocytes from young individuals with low or high BMD. WGCNA… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Multiple Genetic Loci for Bone Mineral Density and Fractures

The New England journal of medicine • 2008
View 7 Excerpts
Highly Influenced

Singular value decomposition for genome-wide expression data processing and modeling.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 3 Excerpts
Highly Influenced

Gene expression profiling in monocytes and SNP association suggest the importance of STAT1 gene for osteoporosis in both Chinese and Caucasians

Chen X-D, P Xiao, Lei S-F
J Bone Miner Res • 2010
View 1 Excerpt

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