Identification of a gene encoding a yeast histone H4 acetyltransferase.

@article{Kleff1995IdentificationOA,
  title={Identification of a gene encoding a yeast histone H4 acetyltransferase.},
  author={Susanne Kleff and Erik D. Andrulis and Carl W. Anderson and Rolf Sternglanz},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 42},
  pages={24674-7}
}
A collection of yeast temperature-sensitive mutants was screened by an enzymatic assay to find a mutant defective in the acetylation of histone H4. The assay used a fractionated cell extract and measured acetylation of a peptide corresponding to amino acids 1-28 of H4. There are at least two activities in this fraction that acetylate the peptide. A mutation, hat1-1, that eliminates one of the activities was identified and mapped to a locus near the centromere of chromosome XVI. The HAT1 gene… CONTINUE READING
75 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…