Identification of a gene encoding a yeast histone H4 acetyltransferase.

  title={Identification of a gene encoding a yeast histone H4 acetyltransferase.},
  author={Susanne Kleff and Erik D. Andrulis and Carl W. Anderson and Rolf Sternglanz},
  journal={The Journal of biological chemistry},
  volume={270 42},
A collection of yeast temperature-sensitive mutants was screened by an enzymatic assay to find a mutant defective in the acetylation of histone H4. The assay used a fractionated cell extract and measured acetylation of a peptide corresponding to amino acids 1-28 of H4. There are at least two activities in this fraction that acetylate the peptide. A mutation, hat1-1, that eliminates one of the activities was identified and mapped to a locus near the centromere of chromosome XVI. The HAT1 gene… CONTINUE READING
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