Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases

@article{Timperio2003IdentificationOA,
  title={Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases},
  author={A. M. Timperio and H. Kuiper and L. Zolla},
  journal={Xenobiotica},
  year={2003},
  volume={33},
  pages={153 - 167}
}
  • A. M. Timperio, H. Kuiper, L. Zolla
  • Published 2003
  • Medicine, Chemistry
  • Xenobiotica
  • 1 Furazolidone, a drug widely used in human and veterinary medicine, exhibits inhibition of monoamine oxidase activity, as observed in the tissues of a number of different animal species, including man. The aim of the current study was to determine which of the two possible metabolites, 3-amino-2-oxazolidone (AOZ) or β-hydroxyethylhydrazine (HEH), a well-known carcinogenic compound, is involved in the toxicological effects reported. 2 A new spectrometric method was set up to differentiate… CONTINUE READING
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