Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases

  title={Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases},
  author={A. M. Timperio and H. Kuiper and L. Zolla},
  pages={153 - 167}
  • A. M. Timperio, H. Kuiper, L. Zolla
  • Published 2003
  • Medicine, Chemistry
  • Xenobiotica
  • 1 Furazolidone, a drug widely used in human and veterinary medicine, exhibits inhibition of monoamine oxidase activity, as observed in the tissues of a number of different animal species, including man. The aim of the current study was to determine which of the two possible metabolites, 3-amino-2-oxazolidone (AOZ) or β-hydroxyethylhydrazine (HEH), a well-known carcinogenic compound, is involved in the toxicological effects reported. 2 A new spectrometric method was set up to differentiate… CONTINUE READING
    14 Citations
    Involvement of active oxygen species in protein and oligonucleotide degradation induced by nitrofurans.
    • L. Zolla, A. M. Timperio
    • Chemistry, Medicine
    • Biochemistry and cell biology = Biochimie et biologie cellulaire
    • 2005
    • 14
    An update on derivatisation and repurposing of clinical nitrofuran drugs.
    • 5
    Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver
    • PDF
    1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer
    • 10
    • PDF
    Metabolism, pharmacokinetics and excretion of the GABAA receptor partial agonist [14C]CP-409,092 in rats
    • 4


    The anti-monoamine oxidase effects of furazolidone.
    • 42
    Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone.
    • 29
    The use of pig hepatocytes to study the nature of protein-bound metabolites of furazolidone: a new analytical method for their detection.
    • 56
    Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics.
    • 47
    • Highly Influential
    Inhibition of monoamine oxidase in chickens and ducklings by a microbial metabolite of furazolidone.
    • 17
    Contribution to the pathobiochemistry of furazolidone-induced oxidative toxicity in chickens.
    • B. Sas
    • Biology, Medicine
    • Acta veterinaria Hungarica
    • 1993
    • 13
    • Highly Influential
    Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein.
    • 44
    Biotransformation of furaltadone by pig hepatocytes and Salmonella typhimurium TA 100 bacteria, and the formation of protein-bound metabolites.
    • 18