Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription

@article{Bagchi1990IdentificationOA,
  title={Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription},
  author={Milan K. Bagchi and Sophia Y. Tsai and Ming-jer Tsai and Bert W O'malley},
  journal={Nature},
  year={1990},
  volume={345},
  pages={547-550}
}
THE steroid hormone, progesterone, enhances transcription in vivo from promoters containing progesterone response elements (PREs)1–5. We have recently shown that the progesterone receptor (PR) modulates transcription in a cell-free system by facilitating the formation of a stable preinitiation complex, apparently through interaction with RNA polymerase II and other basic transcription factors6,7. The precise role of ligand in this activation process remains unclear, however. In order to dissect… CONTINUE READING

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