Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

@article{Perfetti2015IdentificationOA,
  title={Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.},
  author={Michael T Perfetti and Brandi M Baughman and Bradley M Dickson and Yunxiang Mu and Gaofeng Cui and Pavel Mader and Aiping Dong and Jacqueline L. Norris and Scott B Rothbart and Brian D. Strahl and Peter J. C. Brown and William P. Janzen and Cheryl H. Arrowsmith and Georges Mer and Kevin M McBride and Lindsey I James and Stephen V Frye},
  journal={ACS chemical biology},
  year={2015},
  volume={10 4},
  pages={1072-81}
}
Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for this target class with cellular activity is a crucial step toward… CONTINUE READING
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