Identification of a forskolin-like molecule in human renal cysts.

@article{Putnam2007IdentificationOA,
  title={Identification of a forskolin-like molecule in human renal cysts.},
  author={William C Putnam and Sarah M Swenson and Gail A. Reif and Darren P Wallace and George M Helmkamp and J. J. Grantham},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 3},
  pages={934-43}
}
Renal cyst enlargement is increased by adenosine cAMP, which is produced within mural epithelial cells. In a search for modulators of cAMP synthesis cyst fluids from 18 patients with autosomal dominant or recessive polycystic kidney disease (PKD) were analyzed, and in 15 of them, a stable lipophilic molecule that increased cAMP levels, stimulated transepithelial chloride and fluid secretion, and promoted the proliferation of human cyst epithelial cells was characterized. With the use of HPLC… CONTINUE READING

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