Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts.

@article{Williard2001IdentificationOA,
  title={Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts.},
  author={Deborah E. Williard and Joseph O Nwankwo and Terry L. Kaduce and Shawn D. Harmon and M Janie Irons and Hugo W. Moser and G V Raymond and Arthur A. Spector},
  journal={Journal of lipid research},
  year={2001},
  volume={42 4},
  pages={501-8}
}
Polyunsaturated fatty acid (PUFA) utilization was investigated in skin fibroblasts cultured from a female patient with an inherited abnormality in lipid metabolism. These deficient human skin fibroblasts (DF) converted 85;-95% less [1-14C]linoleic acid (18:2n-6) to arachidonic acid (20:4n-6), 95% less [3-14C]tetracosatetraenoic acid (24:4n-6) to docosapentaenoic acid (22:5n-6), and 95% less [1-14C]-linolenic acid (18:3n-3) and [3-14C]tetracosapentaenoic acid (24:5n-3) to docosahexaenoic acid… CONTINUE READING
19 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

fects of dietary n - 3 fatty acid deficiency and repletion in the guinea pig retina

  • R. Wilson, R. J. Henderson, I. C. Burkow, J. R. Sargent
  • Invest . Ophthalmol . Vis . Sci .
  • 1999

Similar Papers

Loading similar papers…