Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.

@article{Graves1992IdentificationOA,
  title={Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.},
  author={Rochelle A. Graves and Peter Tontonoz and Kathryn A. Platt and Susan R Ross and Bruce M. Spiegelman},
  journal={Journal of cellular biochemistry},
  year={1992},
  volume={49 3},
  pages={219-24}
}
The molecular basis for adipose-specific gene expression is not known. To approach the problem of adipocyte gene expression, we have analyzed in detail the capacity of the 5'-flanking region of the adipocyte P2 (aP2) gene to direct cell-type specific gene expression. Although the proximal promoter containing AP-1 and C/EBP binding sites is capable of directing differentiation-dependent gene expression in cultured adipocytes, these constructs are essentially inactive in the tissues of transgenic… CONTINUE READING

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