Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.

@article{Nogami2004IdentificationOA,
  title={Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.},
  author={Keiji Nogami and Kirsty A Lapan and Qian Zhou and Hironao Wakabayashi and Philip J. Fay},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 16},
  pages={15763-71}
}
We recently demonstrated that the residues 337-372, comprising the acidic C-terminal region in A1 subunit, interact with factor Xa during the proteolytic inactivation of factor VIIIa (Nogami, K., Wakabayashi, H., and Fay, P. J. (2003) J. Biol. Chem. 278, 16502-16509). We now show this sequence is important for factor Xa-catalyzed activation of factor VIII… CONTINUE READING