Identification of a factor IX binding site on the third apple domain of activated factor XI.

@article{Sun1996IdentificationOA,
  title={Identification of a factor IX binding site on the third apple domain of activated factor XI.},
  author={Yunguang Sun and David Gailani},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 46},
  pages={
          29023-8
        }
}
Activated factor XI (factor XIa) participates in blood coagulation by activating factor IX. Previous work has demonstrated that a binding site for factor IX is present on the noncatalytic heavy chain of factor XIa (Sinha, D., Seaman, F. S., and Walsh, P. N. (1987) Biochemistry 26, 3768-3775). Recombinant factor XI proteins were expressed in which each of the four apple domains of the heavy chain (designated A1 through A4) were individually replaced with the corresponding domain from the… CONTINUE READING
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