Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.

@article{Desai2005IdentificationOA,
  title={Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.},
  author={Rajeev I. Desai and Theresa A. Kopajtic and Mikhail N. Koffarnus and Amy Hauck Newman and Jonathan Katz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 8},
  pages={1889-93}
}
There is a large unmet medical need for cocaine addiction treatments. Studies have indicated that the dopamine transporter (DAT) is the primary biological target of cocaine, and most drugs that have DAT affinity have behavioral effects like those of cocaine. However, analogs of benztropine have high DAT affinity and behavioral effects that show varying degrees of similarity to cocaine. We now report the discovery that a benztropine analog, JHW007, with high affinity for the DAT does not have… CONTINUE READING

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Evaluation of interactions between histamine H1 antagonist and cocaine effects as a mechanism for the decreased cocaine-like effects of benztropine analogs

  • VC Campbell, TA Kopajtic, AH Newman, JL Katz
  • Soc Neurosci Abstr
  • 2002
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