Identification of a divergent M protein gene and an M protein-related gene family in Streptococcus pyogenes serotype 49.

@article{Haanes1989IdentificationOA,
  title={Identification of a divergent M protein gene and an M protein-related gene family in Streptococcus pyogenes serotype 49.},
  author={Elizabeth J Haanes and Patrick P. Cleary},
  journal={Journal of bacteriology},
  year={1989},
  volume={171 12},
  pages={6397-408}
}
The antigenically variant M protein of Streptococcus pyogenes enhances virulence by promoting resistance to phagocytosis. The serum opacity factor (OF), produced by a subset of M serotypes, is also antigenically variant, and its antigenic variability exactly parallels that of M protein. OF-positive and OF-negative streptococci are also phenotypically distinguishable by a number of other criteria. In order to study the differences between OF-positive and OF-negative streptococci, we cloned and… CONTINUE READING

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